The bioavailability of heavy metals in compost is critical for their agronomic value. The effect of inorganic additives (rock phosphate, PR and boron waste, BW) on Copper (Cu) and Zinc (Zn) bioavailability during co-compost of swine manure and rice straw was assessed using sequential extraction procedure (European Community Bureau of Reference). The result showed that both additives, applied at rates of 2.5%-7.5% (w/w) could promote the change of exchangeable Cu and reducible Cu into oxidizable Cu, thereby reducing their bioavailability factor (BF) by 15.5%-47.2%. While additives provided no significant reduction in BF of Zn, the shift from exchangeable Zn into reducible Zn can still reduce the mobility of Zn. Based on redundancy analysis (RDA), organic matter (OM) and electrical conductivity (EC) were identified as the most important controlling factors for redistribution of Cu and Zn fractions during composting. The inorganic additives strengthened the passivation of Cu and Zn bioavailability by stimulating OM degradation. The 7.5% (w/w) rock phosphate showed best passivating effect on the bioavailability of Cu.